Which medical history is characteristic of immunoglobulin A (IgA) nephropathy?

Updated: May 19, 2020
  • Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Patients with Iga nephropathy may be asymptomatic, with persistent microscopic hematuria and proteinuria and often hypertension. This presentation occurs mostly in adults. Impairment of renal function can occur in such cases, and remission is uncommon. 

Symptomatic presentations in patients with IgA nephropathy include the following:

  • Episodic gross hematuria
  • Rapidly progressive glomerulonephritis –  This is sometimes seen as a late presentation; these patients  may progress to needing renal replacement therapy rapidly.
  • Proteinuria- less than 3 gms/day. (More common)
  • Nephrotic syndrome – More than 3.5 gms of proteinuria with edema, hypoalbuminemia, hypertension, and hyperlipidemia.
  • Chronic renal failure 

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