How is the MEST-C score used for prognostication of immunoglobulin A (IgA) nephropathy?

Updated: Feb 15, 2018
  • Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The clinical significance of the individual MEST-C features is as follows:

  • M1- Worse outcomes than M0
  • E1- Worse renal survival in patients not on immunosuppression and improved renal survival with immunosuppression
  • S1- Predictive of worse outcomes
  • T- Strongest predictor of worse outcomes
  • C1 - Predictive of worse outcomes if no immunosuppression is given, but not if immunosuppression is used; C2 is predictive of worse outcomes regardless of Immunosuppression

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