What is the role of sodium bicarbonate in the treatment of chronic glomerulonephritis?

Updated: Feb 24, 2020
  • Author: Moro O Salifu, MD, MPH, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Sodium bicarbonate has been shown to reduce tubulointerstitial injury and endothelin production with substantial benefits in slowing progressive kidney damage. In one study on patients with advanced kidney failure, the administration of sodium bicarbonate preserved GFR decline. [20] Even in patients with relatively preserved GFR in stage 2 CKD, the administration of sodium bicarbonate was shown to preserve kidney function over 5 years. [21] A study in patients with stage 4 CKD found that 1 year of consuming a diet that included fruits and vegetables dosed to reduce dietary acid by half had effects comparable to those of daily oral sodium bicarbonate at 1.0 mEq/kg per day. [22]


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