Which medications in the drug class Sulfonylureas are used in the treatment of Diabetic Nephropathy?

Updated: Oct 09, 2019
  • Author: Vecihi Batuman, MD, FASN; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Sulfonylureas

Sulfonylureas act primarily by stimulating release of insulin from beta cells. Extrapancreatic actions include increasing the number of insulin receptors and enhancing insulin-mediated glucose transport independent of increased insulin binding. The use of oral agents has decreased because more emphasis is placed on better control as a means of slowing the development of late complications.

Sulfonylureas are indicated for some patients with relatively mild disease. Commonly used sulfonylureas include chlorpropamide, tolazamide, tolbutamide, glyburide, and glipizide.

Chlorpropamide (Diabinese)

Chlorpropamide is a first-generation sulfonylurea that stimulates release of insulin from pancreatic beta cells.

Tolazamide (Tolinase)

Tolazamide is a first-generation sulfonylurea that stimulates release of insulin from pancreatic beta cells.

Tolbutamide (Orinase)

Tolbutamide is a first-generation sulfonylurea that stimulates release of insulin from pancreatic beta cells.

Glyburide (DiaBeta, Micronase)

Glyburide is a second-generation sulfonylurea that stimulates release of insulin from pancreatic beta cells.

Glipizide (Glucotrol)

Glipizide is a second-generation sulfonylurea that stimulates release of insulin from pancreatic beta cells.


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