Which medications in the drug class Antidiabetics, Amylinomimetics are used in the treatment of Diabetic Nephropathy?

Updated: Oct 09, 2019
  • Author: Vecihi Batuman, MD, FASN; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Antidiabetics, Amylinomimetics

These agents are amylin analogs; amylin is co-secreted by βcells with insulin and is deficient in diabetes. Its levels parallel insulin levels, and its actions are complementary to insulin in regulating plasma glucose concentration. Amylin slows gastric emptying, reduces postprandial glucagon, and can suppress appetite.

Pramlintide (SymlinPen 120, SymlinPen 60)

Pramlintide is a synthetic analog of human amylin, a naturally occurring hormone made in pancreas βcells. It slows gastric emptying, suppresses postprandial glucagon secretion, and regulates food intake due to centrally mediated appetite modulation. It is indicated to treat type 1 or type 2 diabetes in combination with insulin. It is administered before mealtime for patients who have not achieved desired glucose control despite optimal insulin therapy. Pramlintide helps achieve lower blood glucose levels after meals, less fluctuation of blood glucose levels during the day, and improvement of long-term control of glucose levels (ie, Hgb A1C levels) compared with insulin alone. Additionally, less insulin use and reduction in body weight is also observed.


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