Which medications in the drug class Calcimimetics are used in the treatment of Chronic Kidney Disease (CKD)?

Updated: Apr 02, 2021
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Calcimimetics

A calcimimetic mimics calcium at the parathyroid hormone (PTH) receptor and reduces PTH levels.

Etelcalcetide (Parsabiv)

Calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR) and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion. It is indicated for secondary hyperparathyroidism in patients with CKD on dialysis.

Cinacalcet (Sensipar)

Cinacalcet directly lowers intact PTH levels by increasing the sensitivity to extracellular calcium of calcium-sensing receptors on chief cells of the parathyroid glands. It also results in a concomitant decrease in serum calcium. It is indicated for secondary hyperparathyroidism in patients with CKD on dialysis.


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