Which extrarenal symptoms may be observed in end-stage renal disease (ESRD)?

Updated: Oct 26, 2020
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Other manifestations of uremia in ESRD, many of which are more likely in patients who are being inadequately dialyzed, include the following:

  • Pericarditis: Can be complicated by cardiac tamponade, possibly resulting in death if unrecognized
  • Encephalopathy: Can progress to coma and death
  • Peripheral neuropathy, usually asymptomatic
  • Restless leg syndrome
  • Gastrointestinal symptoms: Anorexia, nausea, vomiting, diarrhea
  • Skin manifestations: Dry skin, pruritus, ecchymosis
  • Fatigue, increased somnolence, failure to thrive
  • Malnutrition
  • Erectile dysfunction, decreased libido, amenorrhea
  • Platelet dysfunction with tendency to bleed

Screen adult patients with CKD for depressive symptoms; self-report scales at initiation of dialysis therapy reveal that 45% of these patients have such symptoms, albeit with a somatic emphasis.

See Presentation for more detail.

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