What is the role of daily cholecalciferol (Vitamin D) in chronic kidney disease (CKD)?

Updated: Oct 26, 2020
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

In a prospective, controlled study, daily vitamin D supplementation decreased albuminuria in patients with stage 3-4 chronic kidney disease (CKD) who had low vitamin D levels and high parathyroid hormone (PTH) levels. The study population was composed of 50 CKD patients with hyperparathyroidism who were given 666 IU of oral cholecalciferol daily and 51 CKD patients without hyperparathyroidism who acted as controls. [67, 68]

At 6 months, cholecalciferol supplementation led to a mean increase in vitamin D (25(OH)D) levels of 53%. Urinary albumin-to-creatinine ratio decreased, from 284 to 167 mg/g, without alterations in other factors that could affect proteinuria. Control patients showed no change.

Changes in 25(OH)D levels were significantly and inversely associated with those in the urinary albumin-to-creatinine ratio , supporting a possible antiproteinuric effect of vitamin D receptor activation. Treated patients also had a mean drop of 13.8% in PTH, with a mild rise in phosphate and calcium-phosphate product. No change was seen in control patients. [67, 68]


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