What equations calculate glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), and how accurate are they?

Updated: Oct 26, 2020
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Alternatively, the Modification of Diet in Renal Disease (MDRD) Study equation could be used to calculate the glomerular filtration rate (GFR). This equation does not require a patient's weight. [46]

However, the MDRD underestimates the measured GFR at levels above 60 mL/min/1.73 m2. Stevens et al found that the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is more accurate than the MDRD Study equation overall and across most subgroups and that it can report estimated GFRs that are at or above 60 mL/min/1.73 m2. [47]

However, a study by Silveiro et al found that both the CKD-EPI and MDRD equations underestimated GFR in patients with type 2 diabetes. [48] The measured GFR was 103 ± 23 mL/min/1.73 m², the CKD-EPI GFR was 83 ± 15 mL/min/1.73 m², and the MDRD GFR was 78 ± 17 mL/min/1.73 m². Accuracy was 67% for the CKD-EPI equation and 64% for the MDRD equation. [48]


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