How do 25(OH)D levels correlate with mortality risk in chronic kidney disease (CKD)?

Updated: Oct 26, 2020
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Many patients with CKD have low circulating levels of 25(OH)D. A study of 1099 patients (mostly men) with advanced CKD found that the lowest tertile of 1,25(OH)(2)D (< 15 pg/mL) was associated with death and initiation of long-term dialysis therapy compared with the highest tertile (> 22 pg/mL). [35] A retrospective cohort study in 12,763 non–dialysis-dependent patients with CKD found that 25(OH)D levels below 15 ng/mL were associated independently with all-cause mortality. [36]


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