What is the role of chronic kidney disease (CKD) in the development of bone disease?

Updated: Oct 26, 2020
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Renal bone disease is a common complication of CKD. It results in skeletal complications (eg, abnormality of bone turnover, mineralization, linear growth) and extraskeletal complications (eg, vascular or soft-tissue calcification).

Different types of bone disease occur with CKD, as follows:

  • High-turnover bone disease from high parathyroid hormone (PTH) levels
  • Low-turnover bone disease (adynamic bone disease)
  • Defective mineralization (osteomalacia)
  • Mixed disease
  • Beta-2-microglobulin–associated bone disease

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