Which factors, other than the underlying disease process and glomerular hypertension, may cause progressive renal injury?

Updated: Oct 26, 2020
  • Author: Pradeep Arora, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Factors other than the underlying disease process and glomerular hypertension that may cause progressive renal injury include the following:

  • Systemic hypertension
  • Nephrotoxins (eg, nonsteroidal anti-inflammatory drugs [NSAIDs], intravenous contrast media)
  • Decreased perfusion (eg, from severe dehydration or episodes of shock)
  • Proteinuria (in addition to being a marker of CKD)
  • Hyperlipidemia
  • Hyperphosphatemia with calcium phosphate deposition
  • Smoking
  • Uncontrolled diabetes

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