What is the prognosis of azotemia?

Updated: Apr 24, 2020
  • Author: Moro O Salifu, MD, MPH, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The prognosis for patients with AKI generally is poor and depends on the severity of the underlying disease and the number of failed organs. Whereas mortality in patients with simple AKI without other underlying disease is 7-23%, that in ICU patients on mechanical ventilation is as high as 80%.

The prognosis of CKD depends on the etiology. Patients with diabetic kidney disease, hypertensive nephrosclerosis, and ischemic nephropathy (ie, large-vessel arterial occlusive disease) tend to have progressive azotemia resulting in ESRD. Different types of glomerulonephritis have major differences in prognosis: some are quite benign and rarely progress to ESRD, whereas others progress to ESRD within months. About 50% of patients with polycystic kidney disease progress to ESRD by the fifth or sixth decade of life.


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