Which medications in the drug class Diuretics, Other are used in the treatment of Azotemia?

Updated: Sep 19, 2018
  • Author: Moro O Salifu, MD, MPH, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Diuretics, Other

Diuretics are used to induce urine output in acute tubular necrosis (ATN) and to treat edema and hypertension. They increase urine excretion by inhibiting sodium and chloride reabsorption at different sites in the nephron.

Furosemide (Lasix)

Furosemide is the drug of choice as a diuretic. It inhibits sodium chloride reabsorption in the thick ascending limb of the loop of Henle.

Hydrochlorothiazide (Microzide)

Hydrochlorothiazide (HCTZ) acts on the distal nephron to impair sodium reabsorption, enhancing sodium excretion. It has been in use for more than 40 years and is generally an important agent for the treatment of essential hypertension.

Chlorothiazide (Diuril)

Chlorothiazide inhibits the reabsorption of sodium in distal tubules, causing increased excretion of sodium and water, as well as of potassium and hydrogen ions.

Metolazone (Zaroxolyn)

Metolazone is given as an adjunct to furosemide in severe edematous states or when furosemide alone does not achieve adequate diuresis. It increases excretion of sodium, water, potassium, and hydrogen ions by inhibiting reabsorption of sodium in distal tubules. Metolazone may be more effective in the setting of impaired renal function.


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