Which medications in the drug class Corticosteroids are used in the treatment of Azotemia?

Updated: Sep 19, 2018
  • Author: Moro O Salifu, MD, MPH, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Corticosteroids

Corticosteroids are potent anti-inflammatory agents and immunosuppressants. They suppress humoral and cellular response to tissue injury, thereby reducing inflammation.

Prednisone

Prednisone is commonly used for many forms of glomerulonephritis and interstitial nephritis. Once the diagnosis is confirmed, a trial of oral prednisone (starting at 1 mg/kg/day and tapering over 6 weeks) may be considered.

Prednisolone (Orapred, Pediapred, Millipred)

Corticosteroids act as potent inhibitors of inflammation. They may cause profound and varied metabolic effects, particularly in relation to salt, water, and glucose tolerance, in addition to their modification of the immune response of the body. Once the diagnosis is confirmed, a trial of oral prednisolone (starting at 1 mg/kg/day and tapering over 6 weeks) may be considered.

Methylprednisolone (Medrol, Solu-Medrol, Depo-Medrol)

Methylprednisolone decreases inflammation by suppressing the migration of PMNs and reversing increased capillary permeability. In severe cases, a trial of intravenous pulse methylprednisolone (1 g for 3 days) may be considered once the diagnosis is confirmed.


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