Which medications in the drug class Angiotensin II Receptor Antagonists (ARBs) are used in the treatment of Proteinuria?

Updated: Mar 25, 2020
  • Author: Beje Thomas, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Angiotensin II Receptor Antagonists (ARBs)

Angiotensin II receptor blockers reduce blood pressure and proteinuria, protecting renal function and delaying the onset of end-stage renal disease.

Candesartan (Atacand)

Candesartan blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II. It may induce more complete inhibition of the renin-angiotensin system than ACE inhibitors do. In addition, candesartan does not affect the response to bradykinin and is less likely to be associated with cough and angioedema. This drug can be used in patients who are unable to tolerate ACE inhibitors.

Eprosartan (Teveten)

Eprosartan is a nonpeptide angiotensin II receptor antagonist that blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II. It may induce more complete inhibition of the renin-angiotensin system than ACE inhibitors do. In addition, eprosartan does not affect the response to bradykinin and is less likely to be associated with cough and angioedema. This drug can be used in patients who are unable to tolerate ACE inhibitors.

Irbesartan (Avapro)

Irbesartan blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II at the tissue receptor site. It may induce more complete inhibition of the renin-angiotensin system than ACE inhibitors do. In addition, it does not affect the response to bradykinin and is less likely to be associated with cough and angioedema.

Losartan (Cozaar)

Losartan blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II. It may induce a more complete inhibition of the renin-angiotensin system than ACE inhibitors do. In addition, Losartan does not affect the response to bradykinin and is less likely to be associated with cough and angioedema. It can be used in patients who are unable to tolerate ACE inhibitors.

Olmesartan (Benicar)

Olmesartan blocks the vasoconstrictive effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptors in vascular smooth muscle. Its action is independent of the pathways for angiotensin II synthesis.

Valsartan (Diovan)

Valsartan is a prodrug that produces direct antagonism of angiotensin II receptors. It displaces angiotensin II from AT1 receptors and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water intake, and hypertrophic responses.

Valsartan may induce more complete inhibition of the renin-angiotensin system than ACE inhibitors do. In addition, it does not affect the response to bradykinin and is less likely to be associated with cough and angioedema. Valsartan can be used in patients who are unable to tolerate ACE inhibitors.


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