How are lipid abnormalities resulting from proteinuria managed?

Updated: Mar 25, 2020
  • Author: Beje Thomas, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Lipid abnormalities are quite common in patients with nephrotic syndrome. No evidence-based recommendations are available for the treatment of hyperlipidemia associated with nephrotic syndrome. Since proteinuria and hyperlipidemia may increase the risk for atherosclerotic disease, it should be treated in the same way as in the general population. 

Dietary measures are usually not very effective and most of these patients do require medication. The treatment of choice is statin therapy. Some studies have reported statins to be renoprotective and decrease levels of proteinuria. [50, 51] Dyslipidemia usually improves once the proteinuria resolves or immunosuppression is started.


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