Which techniques are used to determine the prognosis of glomerular proteinuria?

Updated: Mar 25, 2020
  • Author: Beje Thomas, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Techniques for calculating proteinuria, to determine prognosis in patients with glomerular proteinuria, include the following [30] :

  • Time-averaged  (obtained from average values over the duration of follow-up
  • Time-varying (calculated from any instantaneous value at any given time point)
  • Time-varying cumulative (obtained from the time-weighted average of all values prior to that same time point)

Results of a study by Kee et al suggest that in patients with glomerular disease, time-varying proteinuria can delineate the association between proteinuria levels and risk of renal progression better than a time-averaged model, as time-varying proteinuria reflects the dynamic change of proteinuria over time. [31]


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