How is membranoproliferative glomerulonephritis (MPGN) classified?

Updated: Mar 25, 2020
  • Author: Beje Thomas, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

MPGN is usually a pattern of injury seen on light microscopy. The current immunofluorescence-based classification divides MPGN as follows [12] :

  • Immunoglobulin- and complement-positive MPGN
  • Complement-positive MPGN - Due to dysregulation of complement pathway; includes C3 glomerulonephritis and dense-deposit disease
  • Thrombotic microangiopathy (immunoglobulin and complement negative)

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