What causes secondary focal glomerulosclerosis?

Updated: Mar 25, 2020
  • Author: Beje Thomas, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Secondary focal glomerulosclerosis may result from the following:

  • The healing phase of other glomerulonephritides
  • As a nonspecific result of reduced nephron mass from any cause, including nonglomerular diseases such as reflux nephropathy
  • Other causes of glomerular hyperfiltration, such as hypertensive nephrosclerosis and obesity

Unlike primary focal segmental glomerulosclerosis, the secondary type usually is gradual in onset and is not usually associated with hypoalbuminemia or other manifestations of nephrotic syndrome, even in the presence of nephrotic-range proteinuria.


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