What causes proteinuria?

Updated: Mar 25, 2020
  • Author: Beje Thomas, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The presence of abnormal amounts or types of protein in the urine may reflect any of the following:

  • Systemic diseases that result in an inability of the kidneys to normally reabsorb the proteins through the renal tubules

  • Overproduction of plasma proteins that are capable of passing through the normal glomerular basement membrane (GBM) and that consequently enter the tubular fluid in amounts that exceed the capacity of the normal proximal tubule to reabsorb them

  • A defective glomerular barrier that allows abnormal amounts of proteins of intermediate molecular weight to enter the Bowman space


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