What is the efficacy of isotonic sodium bicarbonate for the prevention of contrast-induced nephropathy (CIN) in acute tubular necrosis (ATN)?

Updated: Mar 15, 2021
  • Author: Sangeeta Mutnuri, MBBS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

A single-center, randomized, controlled trial demonstrated that isotonic sodium bicarbonate (3 mL/kg/h given 1 h prior to the contrast-requiring procedure and then continued at 1 mL/kg/h for 6 h post procedure) may offer even greater protection than isotonic sodium chloride. [33]  The postulated mechanism is being attributed to the inhibition of oxidant injury by the administered alkali.


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