How is contrast-induced nephropathy (CIN) in acute tubular necrosis (ATN) prevented?

Updated: Mar 15, 2021
  • Author: Sangeeta Mutnuri, MBBS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

For contrast-induced nephropathy (CIN) from the use of radiocontrast dye, isotonic sodium chloride solution infusion has proven benefits as a preventive measure. [32]  Typically, isotonic sodium chloride solution (0.9%) administered at a rate of 1 mL/kg/h 12 hours before and 12 hours after the administration of the dye load is most effective, especially in the setting of prior renal insufficiency and diabetes mellitus. This has been shown to be superior to half normal saline infusions.


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