What is the prevalence of acute tubular necrosis (ATN)?

Updated: Mar 15, 2021
  • Author: Sangeeta Mutnuri, MBBS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The landmark PICARD (Program to Improve Care in Acute Renal Disease) study was an observational study of a cohort of 618 patients with acute kidney injury in the intensive care units of 5 academic centers in the United States. Ischemic ATN was the presumed etiology for 50% of all patients with renal failure, an additional ~12% due to unresolved pre-renal factors, and ~25% from nephrotoxic ATN. [12]  These data were similar to those from the Madrid Acute Renal Failure Study Group, which assessed 748 cases of acute injury from that region of Spain and estimated that the incidence of ATN was 88 cases per million population. [13]

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