Which exogenous nephrotoxins can cause acute tubular necrosis (ATN)?

Updated: Mar 15, 2021
  • Author: Sangeeta Mutnuri, MBBS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Other exogenous nephrotoxins that can cause ATN include the following:

  • Cyclosporine and tacrolimus (calcineurin inhibitors)
  • Cisplatin
  • Ifosfamide
  • Foscarnet
  • Pentamidine, which is used to treat  Pneumocystis jiroveci infection in immunocompromised individuals (risk factors for nephrotoxicity include volume depletion and concomitant use of other nephrotoxic antibiotic agents, such as aminoglycosides, which is common practice in the immunosuppressed)
  • Sulfa drugs
  • Acyclovir and indinavir
  • Tenofovir
  • Mammalian target of rapamycin (mTOR) inhibitors (eg, everolimus, temsirolimus) [8]

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