What is the pathophysiology of acute tubular necrosis (ATN)?

Updated: Mar 15, 2021
  • Author: Sangeeta Mutnuri, MBBS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Acute tubular necrosis (ATN) follows a well-defined three-part sequence of initiation, maintenance, and recovery (see below). The tubule cell damage and cell death that characterize ATN usually result from an acute ischemic or toxic event. Most of the pathophysiologic features of ischemic ATN, as described below, are shared by the nephrotoxic forms.

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