What is the role of trimethoprim-sulfamethoxazole (Bactrim) in intravenous-to-oral switch therapy?

Updated: Jul 30, 2018
  • Author: Shirin A Mazumder, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Answer

Trimethoprim-sulfamethoxazole (Bactrim) can also be used as part of IV-to-PO switch regimens. In 2002, Gollin et al reported on a study of 80 children who underwent appendectomy for perforated appendicitis. The children were safely discharged home on a 7-day course of oral trimethoprim-sulfamethoxazole and metronidazole when enteral intake was tolerated, regardless of fever or leukocytosis. [41]


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