What is the role of ertapenem in intravenous-to-oral switch therapy?

Updated: Jul 30, 2018
  • Author: Shirin A Mazumder, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

The efficacy and safety of intravenous ertapenem (1 g/d) with the option to switch to an oral agent for treatment of adults with complicated urinary tract infections were compared with those of intravenous ceftriaxone (1 g/d) with the same oral switch option in a multicenter, double-blinded, prospective randomized study. The frequency and severity of drug-related adverse events were generally similar in both treatment groups. In this study, ertapenem was as effective as ceftriaxone for the initial treatment of complicated urinary tract infections in adults, was generally well tolerated, and had a similar overall safety profile. [38]


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