What is the role of clarithromycin in intravenous-to-oral switch therapy?

Updated: Jul 30, 2018
  • Author: Shirin A Mazumder, MD, FIDSA; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Clarithromycin can also be used to in an IV-to-PO switch regimen. In 2000, Parola et al reported on 290 patients with CAP who were given clarithromycin at 500 mg twice daily, first given intravenously in 250 or 500 mL of saline solution and then switched after 4-5 days to the same dose given orally. Within 10-15 days, 261 (90%) of 290 patients improved clinically and radiologically. [36]


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