What medications are used in the treatment of Acinetobacter?

Updated: Nov 27, 2018
  • Author: Shirin A Mazumder, MD, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Medications to which Acinetobacter is usually sensitive include the following [4, 8, 9, 10, 11] :

  • Meropenem

  • Colistin

  • Polymyxin B

  • Amikacin

  • Rifampin

  • Minocycline

  • Tigecycline

In general, first-, second-, and third-generation cephalosporins, macrolides, and penicillins have little or no anti-Acinetobacter activity, and their use may predispose to Acinetobacter colonization. Some strains are sensitive to cefepime, ceftazidime, and sulbactam-containing beta-lactam/beta-lactamase–inhibitor drugs.

Monotherapy and combination therapy has been used successfully (eg, amikacin, minocycline, or colistin ± rifampin). Combination therapy is often discussed and suggested, but data proving lower failure rates or lower rates for the development of resistance are inconclusive.

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