What is the pathophysiology of Acinetobacter infection?

Updated: Nov 27, 2018
  • Author: Shirin A Mazumder, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

When Acinetobacter causes actual infection, the pathological changes that occur depend on the organ system involved. The pathological changes, as observed in patients with pneumonia, are indistinguishable from those caused by other noncavitating aerobic gram-negative bacilli that cause nosocomial pneumonias. Similarly, Acinetobacter urinary tract infections are clinically indistinguishable from catheter-associated bacteremias caused by other aerobic gram-negative bacilli.

The predominant predispositions to infection include colonization pressure, exposure to broad-spectrum antibiotics, and disruption of anatomical barriers. [1]


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