What is the prognosis of chronic fatigue syndrome (CFS)?

Updated: Aug 29, 2018
  • Author: Jefferson R Roberts, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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CSF has no cure, its symptoms can persist for years, and its clinical course is punctuated by remissions and relapses. One prospective study suggests that approximately 50% of patients with CSF can return to part-time or full-time work. [14] Longer duration of illness, severe fatigue, comorbid depression, and anxiety are factors associated with a poorer prognosis. [15] Good outcomes are associated with less fatigue severity at baseline, a sense of control over symptoms, and no attribution of the illness to a physical cause. [16] Despite the considerable burden of morbidity associated with CFS, there is no evidence of an increased risk of mortality.

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