Which medications in the drug class Antibiotics are used in the treatment of Ehrlichiosis?

Updated: Jun 22, 2021
  • Author: Chinelo N Animalu, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Antibiotics

Empiric antimicrobial therapy should cover the most likely pathogens in the context of the clinical setting.

Doxycycline (Vibramycin, Doryx, Adoxa)

This is a second-generation tetracycline. It is more active than tetracycline against many pathogens. Doxycycline has different pharmacokinetics and a different adverse effect profile from tetracycline.

Doxycycline inhibits protein synthesis and thus bacterial growth by binding with 30S and, possibly, 50S ribosomal subunits of susceptible bacteria.

Rifampin (Rifadin)

Rifampin inhibits ribonucleic acid (RNA) synthesis in bacteria by binding to the beta subunit of deoxyribonucleic acid (DNA)-dependent RNA polymerase, which, in turn, blocks RNA transcription.


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