What is the role of a buffy coat smear in the diagnosis of ehrlichiosis?

Updated: Jun 22, 2021
  • Author: Chinelo N Animalu, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Buffy coat examination may reveal morulae, which are diagnostic characteristics of HME/HGA. Morulae are observed in the cytoplasm of neutrophils in patients with HGA and in monocytes in patients with HME. Only a minority of patients with HME have detectable morulae.


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