What is the role of aminoglycosides in the treatment of ventilator-associated pneumonia (VAP)?

Updated: Sep 30, 2020
  • Author: Burke A Cunha, MD; Chief Editor: John L Brusch, MD, FACP  more...
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In general, aminoglycosides should be avoided in the treatment of VAP. This also holds true for colistin. This recommendation is most likely based on poor penetration of these agents in the lung tissue, in addition to the potential nephrotoxicity of aminoglycosides and the challenge in achieving therapeutic blood levels in patients with fluctuating renal function.

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