In which patients is a single antibiotic with activity against P aeruginosa contraindicated?

Updated: Sep 30, 2020
  • Author: Burke A Cunha, MD; Chief Editor: John L Brusch, MD, FACP  more...
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Answer

Answer

A single antibiotic with activity against P aeruginosa should be administered, except in patients with risk factors for multidrug-resistant (MDR) organisms, including the following:

  • Intravenous antibiotic use within the preceding 90 days
  • Septic shock or ARDS preceding VAP
  • Five or more days of hospitalization prior to VAP onset
  • Acute renal replacement therapy prior to the onset of VAP
  • The patient is located where more than 10% of gram-negative isolates are resistant
  • Patients in ICUs where antibiotic sensitivity rates are not available

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