What is the role of aerobic gram-negative bacilli in the etiology of hospital-acquired pneumonia (HAP)?

Updated: Jul 30, 2018
  • Author: Burke A Cunha, MD; Chief Editor: John L Brusch, MD, FACP  more...
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Answer

Answer

Because aerobic gram-negative bacilli (eg, Pseudomonas aeruginosa) are the major pathogens associated with HAP, the pathophysiology of nosocomial pneumonia relates to the destructive effect on lung tissue. Aerobic gram-negative pathogens may be divided into 2 categories. The first category includes organisms that cause necrotizing pneumonia with rapid cavitation, microabscess formation, blood-vessel invasion, and hemorrhage (eg, P aeruginosa). [8] Alternatively, other nonnecrotizing gram-negative bacilli (eg, Serratia marcescens) may be responsible for nosocomial pneumonia.


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