What are risk factors for bacterial sepsis and septic shock?

Updated: Feb 05, 2019
  • Author: Amber Mahmood Bokhari, MBBS; Chief Editor: Michael Stuart Bronze, MD  more...
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Risk factors for sepsis and septic shock include the following:

  • ICU admission with subsequent nosocomial infection
  • Bacteremia
  • Advanced age (≥65 years)
  • Immunosuppression - Conditions that impair host defenses such as seen with neoplasms, renal failure, hepatic failure, AIDS, asplenism, diabetes, autoimmune diseases, organ transplant, alcoholism, and the use of immunosuppressant medications and immunomodulators
  • Community-acquired pneumonia
  • Previous hospitalization and antibiotic therapy in the preceding 90 days
  • Genetic factors - Defects of cellular and humoral immunity (low or absent antibody production, T cells, phagocytes, natural killer cells, complement)
  • Urosepsis due to benign prostatic hypertrophy (BPH) in older males or complicated UTI
  • Major trauma and burn injuries

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