What are treatment options for community-acquired pneumonia (CAP) in patients with comorbidities?

Updated: Oct 31, 2019
  • Author: Stephanie L Baer, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Treatment options for CAP in patients with comorbidities such as chronic heart, lung, liver, or renal disease; diabetes mellitus; alcoholism; malignancy; asplenia; immunosuppression; prior antibiotics within 90 days; or other risk factors for drug-resistant infection include the following:

  • Beta-lactam (high-dose amoxicillin 1 g 3 times/day, amoxicillin/clavulanate 2 g/125 mg twice daily or 500 mg/125 mg three times daily or 875 mg/125 mg twice daily, cefpodoxime 200 mg twice daily, or cefuroxime 500 mg twice daily) plus a macrolide or doxycycline OR
  • Respiratory fluoroquinolones (moxifloxacin 400 mg daily, levofloxacin 750 mg daily)

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