Which medications in the drug class Tetracyclines are used in the treatment of Meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Tetracyclines

Tetracyclines inhibit protein synthesis and, therefore, bacterial growth by binding with 30S and possibly 50S ribosomal subunits of susceptible bacteria. They are broad-spectrum bacteriostatic antibiotics that are used to treat infections caused by many gram-positive and gram-negative bacteria. They are contraindicated in children younger than 8 years of age, because they can cause tooth discoloration and bone growth retardation.

Doxycycline (Doryx, Adoxa, Doxy 100, Monodox, Oracea)

Doxycycline can be administered twice daily and is available in both intravenous (IV) and oral formulations. It is less likely to cause photosensitivity than other tetracyclines are. The maximum serum concentration of an IV dose of doxycycline occurs within 30 minutes of administration. The use of doxycycline in meningitis is limited to cases of Brucella or rickettsial meningitis.


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