What is the treatment for Sporothrix schenckii (S schenckii) meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The lipid formulation of amphotericin B is the recommended initial treatment; after the patient responds, itraconazole (200 mg twice daily) is recommended as step-down therapy and should be given to complete a total of at least 12 months of therapy. [43] Using itraconazole to achieve lifelong suppression may be attempted after initial therapy with amphotericin B. Fluconazole is less active against Sporothrix than itraconazole is.


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