What is the treatment for meningitis caused by Coccidioides immitis (C immitis)?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The preferred treatment for meningitis caused by C immitis is oral fluconazole (400 mg/day). Some physicians initiate therapy with a larger dose of fluconazole (as high as 1000 mg/day) or with a combination of fluconazole and intrathecal amphotericin B. Itraconazole (400-600 mg/day) has been reported to be comparably effective. Lifelong treatment is usually required. (See Coccidioidomycosis.)


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