What is induction and consolidation therapy for cryptococcal meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Induction and consolidation therapy for cryptococcal meningitis in patients who do not have AIDS and are not transplant recipients involves giving amphotericin B (0.7-1 mg/kg/day) plus flucytosine (100 mg/kg/day) for at least 4 weeks. Treatment may be extended to 6 weeks in patients with neurologic complications. After this initial period, fluconazole (400 mg/day) is given for at least 8 weeks. LP is recommended after 2 weeks to document sterilization of the CSF. If the infection persists, longer induction therapy is recommended (6 weeks).


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