How is intracranial pressure (ICP) reduced in cases of cryptococcal meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

In many cases, cryptococcal meningitis is complicated by increased ICP. Measuring the opening pressure during the LP is strongly advised. Efforts should be made to reduce such pressure through repetition of LP or insertion of a lumbar drain or a shunt. Medical maneuvers, such as administration of mannitol, have also been used.

The role of newer triazoles, such as voriconazole and posaconazole, has not been investigated. Echinocandins do not have activity against cryptococcus.


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