How are intrathecal antibiotic dosages determined for bacterial meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Intrathecal antibiotic dosages have been determined empirically and are adjusted on the basis of the CSF concentrations of the agent. Typical daily doses are as follows [41] :

  • Vancomycin: 5-20 mg

  • Gentamicin: 1-2 mg in infants and children, 4–8 mg in adults

  • Amikacin: 30 mg (range, 5-50 mg)

  • Polymyxin B: 2 mg in infants and children, 5 mg in adults

  • Colistin (usually formulated as colistimethate sodium): 10 mg once daily or 5 mg every 12 hours

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