What is the role of acid-fast bacillus (AFB) stain in the diagnosis of meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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The demonstration of AFB (eg, with auramine-rhodamine stain, Ziehl-Neelsen stain, or Kinyoun stain) in the CSF is difficult and usually requires a large volume of CSF. Meningeal biopsy, with the demonstration of caseating granulomas and AFB on the smear, offers a higher yield than the CSF AFB smear.

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