Is fungal serology or cerebrospinal fluid (CSF) culture more commonly used in the workup of fungal meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

More commonly, fungal serology (eg, presence of histoplasma antigen in the CSF) is used in the diagnosis of many cases of fungal meningitis because isolating these organisms from culture has proved difficult. It should be noted, however, that the serology for B dermatitidis is not accurate and a negative serology finding does not rule out the diagnosis.


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