What does elevated opening pressure in lumbar puncture (LP) and cerebrospinal fluid (CSF) indicate in meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Elevated opening pressure correlates with increased risk of morbidity and mortality in bacterial and fungal meningitis. In bacterial meningitis, elevated opening pressure (reference range, 80-200 mm H2 O) suggests increased intracranial pressure (ICP) from cerebral edema. In viral meningitis, the opening pressure is usually within the reference range. The CSF opening pressure may be elevated at times in cryptococcal meningitis, suggesting increased ICP, and it is usually elevated in tuberculous meningitis.

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