When is latex agglutination or counterimmunoelectrophoresis (CIE) indicated in the evaluation of suspected meningitis?

Updated: Jul 16, 2019
  • Author: Rodrigo Hasbun, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Latex agglutination or counterimmunoelectrophoresis (CIE) of blood, urine, and CSF for specific bacterial antigens is occasionally recommended if diagnosis is challenging or in patients with partially treated meningitis. The Binax NOW S pneumoniae antigen test, if done on CSF, has a 99%-100% sensitivity and specificity and can even be positive despite prior antibiotic therapy. [25]


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