Which medications in the drug class Corticosteroids are used in the treatment of Acute Sinusitis?

Updated: Mar 01, 2018
  • Author: Itzhak Brook, MD, MSc; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Corticosteroids

Intranasal steroids have not been conclusively shown to be of benefit in cases of acute sinusitis. Study results conflict, with some reporting benefit as monotherapy or in combination with antibiotics and others reporting no benefit (combination or monotherapy).

Beclomethasone, intranasal (Beconase AQ, QNASL)

Beclomethasone has potent vasoconstrictive and anti-inflammatory activity. It has a weak hypothalamic-pituitary-adrenocortical (HPA) axis inhibitory potency when applied topically.

Triamcinolone inhaled (Nasacort, Nasacort AQ)

Triamcinolone decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability.

Flunisolide intranasal

Flunisolide inhibits bronchoconstriction mechanisms, producing direct smooth muscle relaxation. It may decrease the number and activity of inflammatory cells, in turn decreasing airway hyperresponsiveness. Flunisolide decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. It does not depress the hypothalamus.


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